Is Histamine Intolerance Causing Your GERD?

Is Histamine Intolerance Causing Your GERD?

Have you been trying to get rid of GERD or heartburn following all of the usual advice – elimination diets, drinking apple cider vinegar and nothing seems to work?  Using over the counter medications?

Maybe there is another reason we get GERD that has very little to do with making too much stomach acid – the usual noted cause of GERD.

Over the holidays, I began to suffer from GERD keeping me up at night and of course, I blamed it on what I was eating and drinking.  Could there be something else going on?

GERD or gastroesophageal reflux disorder is a really a disruption of the normal hormones of our digestive system that regulates the production of stomach acid, digestive enzymes, and flow of stomach contents.  Phew!

Hormones that are released from the hypothalamus (brain) signals the release of hydrochloric acid (HCL) and gastrin as soon as we smell, taste, see or even the thought of food occurs.  Enzymes to break down protein in our food are also released at this time.

Without HCL and these enzymes, proteins are not completely broken down and that leads to a myriad of side effects including the lack of absorption of vitamin B12, dysbiosis, SIBO and for some chronic fatigue.

In the second phase of digestion, hormones are released that reduce the acidity and instruct the release of the stomach content into the small intestine.

If there is a reduction of these hormones, the content of the stomach just sits there.  Eventually, it can back up and force relaxation of the esophagus – leading to the feeling of heartburn, coughing, pain and even ulcers.

This signally process can also be disrupted if the stomach content pH is too high or other words not acidic enough.  The acid level of our stomach content is what signals the gut to move forward with the release bicarbonate to make stomach content more alkaline and safer to enter the small intestine.

The continued use of antacids will slow down the whole digestion process

What causes the disruption of these digestive hormones?

  • Standard American Diet – High in sugar, unhealthy fats, processed food, commercially raised meats and low in healthy vegetables and fruits.
  • Medications – Asthma Medications, Calcium Channel Blockers (Blood Pressure Meds), Birth Control, Sleeping Meds, Anti-depressants
  • Antibiotic Use – This leads to dysbiosis and eventually can promote GERD.  This especially true with the chronic use of antibiotics.
  • Gut Flora Imbalances or Dysbiosis – Most people who suffer from GERD also suffer from IBS (constipation and diarrhea), SIBO,  and leaky gut.
  • Estrogen Imbalance – Estrogen dominance which can occur even with post-menopausal women, has been found to be a factor in GERD.
  • Chronic Stress – The release of digestive hormones can be disrupted when we are under chronic stress.
  • Histamine Intolerance – A food intolerance that lead to increased stomach acid production.

Most medications like Prilosec, Zantac, and even Tums can be even more disruptive overtime on this hormonal balance and lead to the very cause of GERD – IBS, and dysbiosis.

High Histamine Foods Psoriaisis

How Does Histamine Intolerance Make GERD Worse?

When we think of histamine, we think of antihistamines that we reach for allergies or allergic reactions.  Histamine has many other functions in our bodies, one of which is the regulation and release of gastric acid.

Not only is histamine produced in our bodies, but some foods are also very high in histamine. Usually, the body manages histamine levels by degrading histamine and eliminating it.  But if histamine levels become too high, we may experience symptoms like acid reflux and acid indigestion.

Histamine intolerance is a food intolerance where we develop an intolerance to foods high in histamine because the process of degrading and blocking histamine from food becomes disrupted.

Some common foods known to cause heartburn, like tomatoes, are also high in histamine.   See my list of common foods high in histamine.  If you are experiencing acid reflux and indigestion, you may want to see if it is from foods high in histamine by using a my food/symptom journal.

As a matter of fact, over-the-counter medications referred to as H2 blockers like Zantac block histamine from signaling the production of stomach acid.  It is not uncommon for me to recommend H2 blockers for my client struggling with histamine intolerance to get relief while we uncover the underlying cause of their histamine intolerances.

How to Prevent GERD or Acid Reflux?

There are some simply lifestyle tips that can help you prevent getting acid reflux.  Most of these also help to promote healthy digestion.

  • Avoid large meals
  • Finish eating 3 hours prior to bed
  • Eat slowly; chew thoroughly
  • Ensure adequate, quality sleep
  • Raise the head of the bed 6-8 inches

In addition to these tips, try to avoid foods that are known to cause heartburn and acid reflux because either weaken the esophageal sphincter or irritate the esophageal:

  • Fats – even healthy fats, i.e. olive oil
  • Chocolate
  • Coffee
  • Mints especially peppermint and spearmint
  • Sugar
  • Alcohol
  • Onions
  • Food sensitivities and intolerances, i.e. histamine

Medications, cigarettes, and over the counter drugs can also lead to acid reflux.  Here is my list of foods and medications that can promote acid reflux.

Are there natural or herbal remedies that can help reduce and prevent GERD?

Herbals Recommendations – Ginger, Aloe Vera, Turmeric and DGL Licorice.  I often recommend a product by Designs for Health – GastroMend works great for those struggle with GERD and for those trying to get off of GERD medications.

Digestive Enzymes –If you are struggling with GERD and acid reflux, then start with a digestive enzyme product that does not promote HCL production like, Similase for sensitive stomach from Integrative Therapeutics.

Get my Fullscript Healthy Digestion Guide Today and Get 15% off!  You will need to sign up for my Fullscript account to access my guide and get your discount.

Struggling with Chronic GERD?

If you struggle with chronic GERD, acid reflux, and indigestion, it might be time to get down the underlying cause and get off of OTC medications.  My Healthy Gut Solutions guides and coaches you through how to finally resolve your digestion conditions using a holistic approach.

Sometimes are digestion symptoms are simply a process of resolving food sensitivities and intolerances like histamine intolerance.  Other times, the solution may be more complicated, like addressing H. pylori overgrowth to microbiome imbalances.

Want to learn more about my programs? Book a Discovery Chat today.

 

Could Your Allergies Be A Food Sensitivity or Intolerance?

Could Your Allergies Be A Food Sensitivity or Intolerance?

nWe often blame our sniffling, sneezing, and watery eyes on those spring flowers, budding trees, and of course, grasses.  But for some of us, we have these allergic reactions year-round – can’t blame that on spring flowers and the budding trees.

Maybe it is not an allergy to something in our environment but to something that we have eaten.  That skin rash or sneezing after we ate something could be a food allergy.  Or, it could a food intolerance.

So, if you are not getting a response from taking medications like an antihistamine, your symptoms might from a food allergy or food intolerance.

But is there a difference between food allergies and food intolerances?

What is a Food Allergy?

Most food allergies are followed with an immediate response and involve skin rashes, swollen lips, and/or tongue and in some cases stuffy nose.  They are also not “dose-dependent”; in other words, you only need to eat a bite to get a reaction.

You will have a higher chance of having a food allergy if you have environmental allergies as there is cross-reaction with environmental allergens and certain foods.

So, if you are allergic to ragweed, there is a high probability that you will be allergic to cucumbers.  Get my guide to see if your environmental allergies might be related to food allergies. 

How can you tell if you have a food allergy?  Well, the immediate reaction is the first clue.  Eat a bite of an apple, get swollen lips, there is a good chance you are allergic to apples.

You can be tested for food allergies using a skin prick test but it is very inaccurate.  Blood or serum tests for food allergies are also highly inaccurate.

If you are going to test for food allergies, make sure that the test is testing for what is referred to as the IgE response, not IgG response.  How do you know?  Check with the lab or the practitioner that you are working with.

Most of the inexpensive and common lab testing for food sensitivities only test for IgG response which is very inaccurate.  Testing for food sensitivities is completely different than testing for food allergies.  Testing for food sensitivities tests for reactions to the sugars in food while testing for food allergies tests for the proteins in food.

Are Food Sensitivities the Same as Food Allergies?

In a nutshell, no.  First, food sensitivities are dosage-dependent and secondly, the reaction is delayed.  So that omelet with 3 eggs may take until the evening to get a response.

Food sensitivity reactions are usually constipation, diarrhea, headaches, joint pain, and brain fog versus the runny nose or sniffles.

The most accurate food sensitivity testing is MRT from Oxford Labs.  Why?  Because they test multiple immune responses to 170 foods and chemicals.   The MRT test is one of the few lab tests that tests for chemicals; some of these chemicals relate to food intolerances like tyramine (think red wine).

Tyramine is a also a close “cousin” to histamine; if you are sensitive to tyramine most likely you are also histamine intolerant.  By the way, both share the genes that help to degrade them.

 

But What About Food Intolerances?

The  most common food intolerance that causes allergic reaction in some people is histamine intolerance.

Most food intolerances are caused by lack of an enzyme or poor gut health (poor microbiome) which supports the breakdown of common food chemicals like histamine and say lactose from dairy products.

Histamine is found the highest in fermented foods, preserved meats, cheese, canned fish and alcoholic beverages.  For some people they will react with sneezing and sniffling after they consume enough histamine rich foods.

Others will react with headaches, migraines, GERD or heartburn, and low blood pressure (some will have high blood pressure depending on their genes).

Almost all food intolerances are related to genomics – nutrigenomics including histamine, lactose, and tryamine.  Certain gene variants will reduce the enzyme function that breakdown food chemicals like histamine, lactose, sulfur, and tyramine.  Other genes will promote histamine production making it harder to balance histamine.

Food intolerance testing – it is very difficult to test for food intolerances and usually a trial and error.  A nutrigenomics test is a great first step as this takes a great deal of work out of the process.

Because histamine intolerance originates in the gut and the predominant enzymes that degrades histamine in mostly produced in our gut, testing for intestinal permeability and the DAO enzyme is currently the most accurate way to test for histamine intolerance.  The best test for this the Advanced Intestinal Barrier Assessment Test by Precision Point.

Advanced Intestinal Barrier Assessment Package

Ever Notice that We Get Allergies as We Get Older?

Maybe it is really is histamine intolerance?  Ever notice those “allergies” get worse as we get older?  There might be a connection here.

As we get older, our digestion can become impaired.  For one, we produce less gastric acid as we get older which means we don’t absorb nutrients from our or breakdown food very well.

It doesn’t help that we also start taking digestive aids like proton pump inhibitors like Prilosec or H2 blockers (Zantac); both of which lower stomach acid reducing the breakdown of foods.

This also leads to partially broken-down food in our digestive system which can feed opportunistic bacteria like yeast in our gut.

Managing histamine levels depends on a healthy gut, balanced microbiota, and nutrients like vitamin B6.  It has been shown that some bacteria actually produce histamine and if you have an overgrowth this will make your more histamine intolerant.

Nutrients like vitamin B6 helps us to produce the enzymes known as diamine oxidase (DAO).  DAO helps to block the absorption of too much histamine and with a reduced function of DAO, it can lead to intolerance.

Managing histamine intolerance can be a challenge but you can reduce your symptoms with natural antihistamine or use dietary supplements that contain quercetin like Thorne's Quercetin Phytosome.

Thorne Quercetin Antihistamine

Nutrigenomics & Histamine Intolerance

For me, my discovery of my histamine intolerance was just using a food journal and trying to connect the dots to my migraines. 

After a while, I realized that the combination of red wine, pizza was sure to trigger for migraine the next day.  All foods are high in histamine even the tomato sauce.

After getting my first genomic test it became crystal clear why had such a tendency towards histamine intolerance.  I had many variants in the pathway that helps to breakdown histamine or block absorption of histamine from food.

Histamine intolerance is related to gene variants in, MTHFR, vitamin B6, HNMT, COMT, and DAO.  And, if you have a reduced function in methylation, this also can impact your metabolism of histamine