Does Supplemental Collagen Reduce Tendon Pain from Being Floxed?

Does Supplemental Collagen Reduce Tendon Pain from Being Floxed?

Does Supplemental Collagen Reduce Tendon Pain from Being Floxed?

Taking fluroquional antibiotics like Cipro has been associated with a significantly increased risk of tendinitis and tendon rupture.   Achilles tendon tear is the number one negative side of these antibiotics, with some people experiencing tendon tear with simple activities like getting out of a car.

My husband said he felt like there was a vice grip on his ankle shortly after he took Levaquin, a fluoroquinolone antibiotic.   His doctor and physical therapist told him to “take it easy” as he may tear his Achilles tendon—a pretty high price to pay for taking an antibiotic for a minor infection.

Fluoroquinolone antibiotic causes this by disrupting the production of collagen, the protein that the body uses to form our skin, tendon, muscles, bones, cartilage, and ligaments.   It might be noted that collagen is also used to form our nerves and nerve pain is another symptom of this toxicity.

What is Collagen?

Collagen is the most abundant protein in the body and is formed from key amino acids (protein building blocks).   The three critical amino acids that the body uses to make collagen is glycine, proline, and lysine.

There are four types of collagen, usually referred to as Type I-IV.   Type 1 and 3 collagen are found in our muscles, tendons, ligaments, skin, and cartilage.   Type 4 is found in our nerves and provides healthy nerve function and repair.

Key Factors in Collagen Production

We often hear of vitamin C as being a critical nutrient that stops the aging process in our skin.  This is because vitamin C plays a pivotal role in the formation of collagen.  Vitamin C is a co-factor in hydroxyproline production, which is a stabilizing factor in the collagen.

Vitamin C also helps iron to signal the production of enzymes that catalyze the reaction to form collagen.  I always like to say, “enzymes make things happen.”   Vitamin C also makes sure that our iron is recycled back into a safe form of iron, reducing oxidative stress.

How Does Fluoroquinolone Toxicity Affect Collagen Synthesis?

Remember that iron plays a role in collagen synthesis?  FQ toxicity reduces iron's ability to produce enzymes that trigger the production of hydroxyproline.

One research study showed the FQ toxicity reduced activity to the three enzymes that trigger collagen and hydroxyproline production.  Reduced hydroxyproline has found to cause significant changes in collagen's mechanical properties, causing the tendons to be stiff and rigid.

Other studies have shown that FQ toxicity enhances the enzymes known as extracellular matrix metalloproteinases, increasing collagen's breakdown, especially in tendons.  This increased breakdown of collagen increases the likelihood of tendonitis and tendon damage.

Supplemental Collagen

 

Fluoroquinolone Toxicity Can Lead to Long Term Tendon Pain & Damage

Have you ever wondered why your tendon pain and damage doesn't seem to go away even months after taking the medication?   This is because the gene expression or “recipe” on how your body creates collagen and hydroxyproline can be changed or altered. This changes the genetic instructions or recipe for healthy collagen faulty.

This change in genetic instructions is known as the science of epigenetics.  Epigenetics is the science of how specific genes that are not encoded in the DNA can be activated or silenced.  I like to think of the DNA as our cells' hardware that really cannot be changed.  Epigenes is like software on your computer that can be changed.

What can change our gene expression?  When the cell's environment is changed due to toxicity, nutrient deficiencies, or chronic stress, those genes can be expressed.  Fluoroquinolone toxicity leads to a gene expression that reduces the enzymes that are responsible for making healthy collagen.

Kale Onions

Can You Reverse Gene Expression Caused by Fluoroquinolone Toxicity?

You can change gene expression by changing the cell environment, reducing oxidative stress, and providing plant nutrients known as bioactives. 

These bioactives are compounds known as polyphenols, and they upregulate a crucial gene known as NrF2.  This gene plays a pivotal role in the production of antioxidants reducing oxidative stress and inflammation.

Fluoroquinolone toxicity, like most toxicity, creates a much higher demand for antioxidants like glutathione.  This toxicity leads to oxidative stress.  By providing polyphenols that upregulate NrF2, you can change gene expression to create healthy collagen.

What are the key polyphenols that can reduce oxidative stress and upregulate NrF2?

  • Lycopene – Tomatoes (cooked only), pink grapefruit, and watermelon.
  • Quercetin – Elderberries, Fennel, Garlic, Onions, Radish Leaves
  • Curcumin – Turmeric*
  • Sulforaphane – Cruciferous Vegetables (Broccoli, Cabbage, Cauliflower, Radish, Kale, Chard)
  • Epigallocatechin (EGCG) – Green Tea, Matcha

NOTE:  Supplemental high dosage turmeric has been found to lead to iron deficiency in some people.  Recommend supplementing with curcumin in the form known as BCM-95.  This form of curcumin has been found to be the best absorbed.  I like this product.  Get 15% off with NutriDyn Sign up Today!  Practitioner Code: 282711

Does Supplemental Collagen Help to Reduce Tendon Pain and Damage Caused by Fluoroquinolone Toxicity?

Supplemental collagen has all of the amino acids to form healthy collagen, making sense to supplement with collagen.  However, it doesn't contain the essential cofactor nutrients that help create collagen, like vitamin C, copper, and vitamin B6.  

Nor does it contain those bioactives or polyphenols that help to change gene expression.  The key to reducing FQ toxicity effects on tendons and nerves is to change the gene expression, thereby increasing the enzymes that produce healthy collagen.

Collagen supplementation would be more beneficial if taken along with these nutrients and bioactives.  Increasing polyphenols and antioxidants also has the bonus of reducing oxidative stress, a significant factor in how FQ toxicity causes so much damage.

 

Vitamin C Rich Foods Collagen

Best Way to Reduce Tendon Pain and Damage Caused by Fluoroquinolone Toxicity

The best way to reduce tendon pain and damage from FQ toxicity is to combine the right foods, supplements, and if needed, supplemental collagen to help your body overcome the toxicity.  And, to change the gene expression to help the body naturally produce healthy collagen.

There are many foods that are naturally high in collagen-like bone broth.  The best way to enjoy bone broth is to make your own but if you are looking for a good bone broth powder, I like Ancient Nutrient bone broths.  I like them because they offer a wide variety of different bone broth made from different sources.  This helps to accommodate those that have food sensitivities to different protein sources, like beef or chicken.  Sign Up Today with my Fullscript and get 15% off.

Overall your diet should be rich in those foods that provide those polyphenols along with healthy sources of protein.  A more plant-based diet like the Mediterranean diet is best as it provides moderate sources of protein, high in vegetables, nuts, seeds, and legumes (beans, lentils). 

Support the process of making collagen instead of trying to supplement it just with collagen.   You can support collagen production with these key nutrients:

  • Vitamin C – Choose a product that is more complete, like C 500 Chewables that is specific to collagen production.  Get 15% off at NutriDyn.
  • Copper – Food high in copper are organ meats, oysters, spirulina, nuts, and seeds.  The leading cause of copper deficiency is taking too much zinc.  Always make sure if you are taking zinc, to also supplement with copper in small amounts.
  • Vitamin B6 – B vitamins should all be taken together in a complex.  It is not uncommon to see deficiencies in vitamin B6 with being floxed and you should get levels tested before using high dosage vitamin B6.  High dosage vitamin B6 can lead to nerve damage, especially in the hands.  
  • Iron – Make sure to test for iron levels as FQ toxicity can disrupt iron metabolism causing excessive iron absorption from food.  For some people that can lead to high levels of oxidative stress.

To help speed up your recovery, try using supplements that help to reduce inflammation and speed up recovery from tendonitis.  My favorite NutriDyn products for pain relief are Chrondo Jointade, Herbal Eze, and Nerve Eze.  These products not only contain essential nutrients that reduce pain, they also contain those nutrients that support healthy collagen products.   These can be found in NutriDyn Floxie Solutions StoreSign up Today and Get 15% off.  Practitioner Code: 282711

 

Collagen Supplementation

What Should You Look for In Collagen Supplementation?

Collagen supplementation along with nutrients like vitamin C, may be beneficial especially for those with genomic variants like COL1A2.  This genetic variant affects how your body produces collagen and it has been shown that supplementing with collagen can help to repair tendon damage more quickly.  Learn more about genomics. 

What should you look for in a collagen supplement?  Collagen is a very large molecule and is hard to break down into the protein building blocks that form collagen. 

In most cases, fluoroquinolone toxicity leads to poor digestion and reduced digestive enzymes. Poor digestion reduces the ability to absorb and breakdown collagen.  Using a collagen supplement that is broken down or in the form of polypeptides would be a better collagen supplement.

Always look for a quality collagen supplement product like this one.  A study done in 2020 found high levels of contamination of lead, mercury, and other heavy metals in some of the top-selling collagen brands. 

Collagen Supplement May Lead to Oxalate Toxicity

Fluoroquinolone antibiotics can lead to oxalate toxicity as it disrupts the gut microbiome and increases the likelihood of vitamin B6 deficiency.   Vitamin B6 plays a crucial role in the breakdown of oxalates.

The body naturally produces oxalates from the breakdown of hydroxyproline for collagen.  Collagen contains high amounts of hydroxyproline.  Therefore supplementing with collagen may lead to oxalate toxicity for some people.

Oxalates can also be formed from glycine, the number amino acid in collagen.  Glycine is produced in a reversible reaction where vitamin B6 acts as a co-factor.

The number one symptom of oxalate toxicity is kidney stones, yet only 7% of people with oxalate toxicity get kidney stones.  Before using collagen supplementation, you may want to rule out oxalate toxicity, as this may be the cause of your joint and tendon pain.   

Not sure if you have oxalate toxicity, get tested today with the Organic Acid Test.  The Organic Acid Test (OAT) is part of my Floxie Solutions because it not only tests for oxalates, it tests for vitamin B6 levels.  To learn more about my Floxie Solutions program, get your complimentary consult today!

References:

  1. Treatment of the Fluoroquinolone-Associated Disability:  The Pathobiochemical Implications
  2. Proline Precursors and Collagen Synthesis:  Biochemical Challenges of Nutrient Supplementation and Wound Healing
  3. Collagen Diet, https://www.medicinenet.com/collagen_diet/article.htm
  4. Primary and Secondary Hyperoxaluria: Understanding the Enigma
  5. Advanced Nutrition and Human Metabolism, Sareen S. Gropper, Jack L. Smith, Sixth Edition

 

How to Overcome Oxalate Toxicity and Avoid Oxalate Dumping

How to Overcome Oxalate Toxicity and Avoid Oxalate Dumping

What is Oxalate Toxicity?

Green smoothies full of spinach, kale, and made with almond milk may seem like a great idea to clean up your diet.  But it also might be the cause of your oxalate toxicity.

Superfoods like spinach, kale, and nuts are high in oxalates, and typically your body naturally eliminates them through healthy digestion and elimination.  However, if oxalates are not eliminated safely and start to build up, this can lead to many health consequences like painful kidney stones.

Oxalate toxicity leads to high levels of oxalates in the urine or what is referred to as hyperoxaluria.  If oxalates are not eliminated properly through the gut, they end up in the kidneys where they don't belong.  There are two types of hyperoxaluria, primary and secondary.

There are genetic mutations with primary hyperoxaluria, which is the most common form of oxalate toxicity.   In the case of these genetic variances, you would have to maintain a low oxalate diet and monitor your kidney health.  You can determine if you have these genetic mutations with the organic acid test and genomics testing.

However, secondary hyperoxaluria has many causes, including increased dietary intake of oxalates, poor gut health, and reduced ability to absorb fat properly.  In addition, dysbiosis or imbalances in gut bacteria can lead to increased absorption of oxalates.

 

Chocolate Nuts High Oxalates

Where do We get Oxalates?

The primary source of oxalates comes from dietary sources and is one reason juicing is coming into question as promoting oxalate toxicity.  Juicing with vegetables and fruits like spinach, kale, beetroot, kiwi, along with nut milk, is exceptionally high in oxalates.  Along with increased fluids from the juicing, the oxalates are more readily absorbed into the gut and not properly eliminated.

We also can get high oxalates from excessive intake of the building blocks of oxalates as our bodies produce oxalates.  For instance, over supplementing with vitamin C, a significant nutrient needed to form oxalates, can increase production.

The compound hydroxyproline, a major component of collagen, is also broken down into oxalates.  Could consuming supplemental collagen that is so popular these days lead to high oxalates?  The answer to this is not clear, but with poor gut health and nutrient deficiencies like vitamin B6, supplementing with collagen can potentially lead to oxalate toxicity.

How do We Get Oxalate Toxicity?

One of the significant causes of oxalate toxicity is poor digestion and fat malabsorption.  When we eat foods high in fat, the liver and gallbladder release bile.  Bile does two things; breakdowns fat into small globules for easy absorption and binds oxalate to calcium for elimination.

Without bile from your liver and gallbladder, you would not be able to absorb and digest fat properly.  The oxalates from your meal would also not be combined with calcium to form a compound that we cannot absorb and is eliminated in the stool.  So instead of removing the oxalates, you absorb them instead, increasing your toxicity.

Nutrient deficiencies can also come into play here, especially vitamin B6 as it is a key co-factor in the breakdown of oxalates into glycine (a significant protein building block).   Nutrigenomics or genomic variances can increase your need for vitamin B6 and other nutrients, increasing your risk for oxalate toxicity.

The microbiome helps to reduce oxalates as they are the energy source for bacteria known as oxalobacter formigenes.   Imbalances in the gut microbiota like candida (yeast) overgrowth can impact the diversity in bacteria, including oxalobacter formigenes that help reduce oxalate absorption.  Again, we are back to gut health.

asparagus food high in sulfur

What are the Symptoms of Oxalate Toxicity?

The number one and most painful symptom of oxalate toxicity is kidney stones.  Because oxalates have a crystal-like structure, they can combine with minerals and form complexes.  These complexes can become embedded into tissue and glands like the thyroid leading to a myriad of symptoms.

Oxalate absorption causes a deficiency in sulfate, a nutrient that plays a crucial role in maintaining a healthy gut, detoxification, and strengthening our bones, ligaments, and tendons.  Wow!  Both sulfate and oxalates depend on the same transporter; whatever we have the most of wins.  For every oxalate molecule absorbed, we lose a sulfate molecule.

For this reason, symptoms of oxalate toxicity also are related to sulfate deficiency, such as hormonal and neurotransmitter imbalances.

  • Fibromyalgia
  • Insomnia
  • Joint Point
  • Eye Pain
  • Fatigue
  • Kidney Stones (calcium oxalate), Gout
  • Thyroid Issues – Hormonal Imbalances
  • Gluten Intolerance
  • IBS – Diarrhea, Constipation or Both
  • Neurotransmitter Imbalance – Low Serotonin in Brain
  • Mineral Deficiencies – Mg, Ca, Potassium

How Do You Determine if You Have Oxalate Toxicity?

The best way to test for oxalate toxicity is the Organic Acid Test (OAT).  This test is one of the few tests that currently tests for oxalates levels.  This simple at-home test also tests for candida (yeast) and fungal infections.  Candida overgrowth has been found to promote oxalate toxicity and must be addressed to overcome high oxalates.

Other values on the OAT test, like nutrient values, open the door for healing opportunities by addressing the underlying cause of your oxalate toxicity.   Learn more about the Vibrant America Organic Acid test.  

Rather than just eliminating vegetables, fruits, nuts, and other foods high in oxalates, you can address the powerful why by completing the OAT Test.

How to Overcome Oxalate Toxicity?

Whereas avoiding foods high in oxalates seems like the logical first step, you would also be avoiding some of the keys foods that are high in sulfur like kale.  Kale and other green leafy vegetables are also high in crucial nutrients that help you detox, support methylation, and heal the gut.  Even chocolate contains key antioxidants; won't it be great to eat chocolate without worry about oxalates?

The three key ways to reduce oxalates are to support the liver/gallbladder, address mineral deficiencies, balance the microbiome, and gradually reduce foods high in oxalates. By gradually reducing foods high in oxalates, you will avoid the condition known as oxalate dumping, making your symptoms worse.

 

What is Oxalate Dumping?

When you drastically reduce foods that contain oxalates, the oxalates that have accumulated will start to move.  Oxalates have a crystal-like structure with sharp edges and create pain as they begin to move out of tissue like the thyroid and into the bloodstream.  Symptoms of oxalate dumping are:

  • Sandy, Grainy Stool
  • Pain w/Urination
  • Moodiness, Irritability
  • Painful Bowel Movement

To avoid oxalate dumping, start very gradually by reducing high oxalate foods by 5-10% per week.  The best way to do this is to start by eliminating the high oxalate foods using this guide.  You can also use an app to track your oxalate content – here are the 5 Solutions for Tracking Oxalates in Your Diet.  But most importantly, as you reduce oxalates, you will need to support your body's natural elimination of oxalates.

How do Your Support the Liver/Gallbladder Reducing Oxalates?

By helping your liver and gallbladder to produce bile, you will eliminate the oxalates safely.  The added bonus would be improved fat absorption and better absorption of fat-soluble vitamins; A, D, E, and K.  Start by making sure you are consuming a diet contains healthy fats; low-fat diets are the perfect way to clog up the gallbladder and liver.

For additional support and healthy elimination of oxalates and reducing fat malabsorption, I recommend using Lipo-Flow by NutriDyn.  This product contains everything you need to improve gallbladder and liver function.  And to eliminate oxalates safely, reducing oxalate toxicity.  Sign up today and get 15% off.

 

Calcium with Meals Eliminates Oxalates Safely

Remember that bile can combine oxalates with calcium forming a complex that we cannot absorb.  This complex is then eliminated through the stool.  By taking calcium supplementation with meals, you can promote the elimination of oxalates safely.  And save your kidneys from forming kidney stones.

I recommend NutriDyn, Cal-Mg-K that is combined with other minerals to support the elimination of oxalates.  This supplement also addresses mineral deficiencies like magnesium, often seen with oxalate toxicity.  Sign up today with NutriDyn and get 15% off.  Remember taking calcium on an empty stomach will lead to oxalate kidney stones; always take with meals.  

You can also eat foods high in calcium like dairy products to help the elimination of oxalates.  Ironically, plant-based foods high in calcium are not effective because the calcium is not readily absorbed.

 

Ditch the Sugar – Balanced Microbiome

Since yeast and fungal overgrowth is often seen with high oxalates, it is recommended that you reduce sugar and fruits to help reduce yeast or candida overgrowth.  By reducing candida overgrowth, you can rebuild the microbiome's diversity, increasing the oxalobacter formigenes that use oxalates for energy.

Ultimately, an OAT test would give you what you needed to do to improve your gut microbiota and reduce your toxicity.  Just taking probiotics does not improve diversity unless you have removed the overgrowth first. 

To rebalance the gut, you would need to address the overgrowth and “reseed” your garden with the right probiotics and prebiotics.  The best probiotics to help rebalance the gut our soil probiotics – Microbiome Labs MegaSpore.  Sign up today for your Fullscript account and get 15% off of Megasporebiotic today!

 

Can a Functional Nutrition Evaluation Identify Oxalate Toxicity?

 

By evaluating your nutritional status through a simple health questionnaire and common lab values, you can determine if oxalate toxicity might be causing your symptoms.  For instance, digestion issues like chronic constipation is a sign of poor gut health and oxalate toxicity.   

The OAT test, however, is the gold standard on not just determining if you have oxalate toxicity, but how you can overcome this toxicity and enjoy chocolate again!

Too often we go down the road of eliminating foods hoping to resolve our symptoms.  Pretty soon we are eliminating those foods that high in key nutrients, like sulfur which can make your symptoms worse. 

Oxalate toxicity is an excellent example of why just eliminating the foods will not resolve the problem.   And, will make things worse as so many of the foods high in oxalates like nuts, kale, spinach, and lentils are high in the nutrients that you need to heal the gut, resolve autoimmune, and overcome Cipro toxicity.

 

Best Probiotics for Histamine Intolerance

Best Probiotics for Histamine Intolerance

What is Histamine Intolerance?

Histamine intolerance can lead to many symptoms but the most common are allergic-type reactions like stuffy nose, watery eyes, and sinus headaches.  We often reach for the anti-histamines to reduce the symptoms when we should be checking out what is in our pantry.

The body produces histamine for many reasons with the most important being defending the body against foreign invaders playing a major role in our immune system.   It is also found in food with fermented foods and leftover meats having some of the highest amounts.

Because our body produces it and it is in our food, our bodies have ways to make sure that histamine stays at healthy levels.  When histamine levels become too high, it can lead to allergic-type reactions.  But not for all of us.

For some of us, myself included, symptoms may vary resulting in migraines, headaches, skin conditions, and even insomnia.  Histamine intolerance is where our bodies are not able to manage healthy levels of histamine resulting in a myriad of symptoms.

Functional Nutrition Rash Histamine Intolerance

Symptoms of Histamine Intolerance

Histamine plays many roles in our body including regulating stomach acid.  It is also an “excitatory neurotransmitter”, brain signaling chemical.  Therefore, it plays a role in brain function and our mental health.

Because histamine plays so many different roles in our bodies, symptoms of histamine intolerance can vary from one person to the next.  This is one of the reasons it is so difficult to determine if you have this food intolerance.  We reach for the antihistamines, pain medications, or more instead of looking at our diet.

Whereas this food intolerance can be identified and resolved, it is difficult to manage as almost foods contain some level of histamine.  There is no such thing as a histamine free diet.

Symptoms of Histamine Intolerance:

  • Itching Skin, Eyes, Ears, and Nose
  • Hives, Skin rashes, Eczema
  • Autoimmune Flares – Psoriasis
  • Low Blood Pressure
  • Increased pulse rate
  • Anxiety, Panic Attacks
  • Headaches – Migraines, Cluster
  • Chest Pain
  • Fatigue, Confusion & Irritability
  • Heartburn, GERD
  • Bloody Noses
  • Sweaty Feet
  • Menstrual Irregularities including PMS

Causes of Histamine Intolerance

As with most food intolerances, it is a lack of an enzyme that leads to intolerance.  An excellent example of this is lactose intolerance with dairy foods.  Lactose intolerance is where we lack enough of the enzyme, lactase, to properly digest the sugars in dairy products.

With histamine, the enzyme known as diamine oxidase (DAO) produced in our gut, works a little differently than the enzyme, lactase.  This enzyme actually blocks the absorption of histamine from the foods that we consume. Thereby reducing and managing histamine levels.

On the other hand, we produce another enzyme known as histamine-N-methyltransferase, (HNMT).  This enzyme actually breaks down histamine thereby reducing levels.  Once levels get too high, HNMT, starts breaking down histamine to a manageable level.

heal the gut woman

What Could Go Wrong with these Two Enzymes?  

The enzyme DAO is produced by the bacteria in the gut as well as our body produces it.  One of the major causes of histamine intolerance is dysbiosis and a condition known as “leaky gut”.

Dysbiosis is a condition where our gut bacteria become imbalanced and, in most cases, we have an infection of bad bacteria.  This leads to a reduction of DAO and we over absorb histamine from our food leading to histamine intolerance.

With HNMT, this enzyme depends on a process known as methylation which produces a compound known as SAMe.  This process depends highly on certain nutrients like folate, vitamin B12, and B2.  If you are deficient in these nutrients or there a great demand for these nutrients, you could become histamine intolerant.

Some of the causes of deficiencies in folate, vitamin B12, and B2 are chronic stress and chronic hidden infections like dysbiosis.   So, you can see that the role of gut health plays a major role in whether you will become histamine intolerant or not.

Looking at the fact that HNMT, needs SAMe one would think that supplementing with SAMe would do the trick.  Unfortunately, like most dietary supplements, it depends on many other factors and nutrients to balance out nutrient deficiencies.

Supplementing with SAMe can lead to anxiety and insomnia, therefore, it is recommended and that you support methylation instead.  Instead, you can promote healthy methylation through consuming foods that are rich in folate like green leafy vegetables and foods rich in vitamin B12 (found mostly in animal products).

Functional Nutrition Heal Histamine Intolerance Wine Pizza

Can you resolve histamine intolerance?

With most food intolerances, you have to first identify if you have it and then it is a matter of managing your food intolerance.  This is for two reasons.

One depends on your genetic makeup as there many different genomic variances that come into play with histamine intolerance.  The other depends on your gut health and being able to maintain a healthy gut and gut microbiota.

The first step to resolving histamine intolerance is to identify if you are histamine intolerance.  Doing a food/symptom journal is a great place to start.  By connecting what you eat to your symptoms you can begin to see if there a connection.

Due to the fact that food intolerances are dosage dependent, in other words, it depends on how much you eat not just what you eat.  You will have to do a food journal for at least 1 week or so.  This is how I found out I was histamine intolerant.

Foods High in Histamine

  • Processed, cured, fermented meat
  • Leftover meat, poultry, pork and fish
  • Fermented milk products like yogurt
  • Seafood: shellfish, fresh, frozen, smoked or canned
  • Fish especially tuna fish (canned)
  • Fermented foods – sauerkraut, kombucha, fermented soy products
  • Tomatoes
  • Artificial food colors and preservatives
  • Chocolate, cocoa and cola drinks
  • Alcoholic Beverages – wine and beer

Almost all foods contain some histamine.  This list does not include all foods high in histamine but includes the most commonly eaten foods high in histamine.

Unlike food allergies, where the response is immediate, food intolerances can take up to 2 days for symptoms to occur.  For me, it was the realization that every time I indulged with a glass of red wine and pizza, I would get a migraine.

All of these foods are high in histamine.  My migraines would usually start up around 3.00 am when histamine release is at its highest for most of us.

Once you have determined if you are histamine intolerant, then you have to try to determine the underlying root cause.  In most cases, healing the gut is key to resolving histamine intolerance.

Begin with my FREE Health Assessment to assess how healthy your gut is and how you can improve your gut health.

You may also have genomic variants that lead to poor enzyme functions like MTHFR, which can increase your need for folate and vitamin B12.  For me, I have the rarest variant in MTHFR as well as variants in both DAO and HMNT.  The key to truly managing your histamine intolerance is genomic testing and evaluation.

With my Optimize Health Genomic Package, you can finally get down to the underlying cause and manage your food intolerances.  Or, you can get started today with Nutrition Genome, reviewing key variants to your overall health, gut health, and potential food intolerances.

 

Are There Probiotic Strains That You Should Avoid?

Yes, definitely.  I learned the hard way on this one.  Trying to experiment with making my own yogurt, I purchased a culture to make my yogurt containing Lactobacillus bulgaricus.  Oops…

Lactobacillus bulgaricus can be found in many popular yogurt brands, i.e. Fage.  Always, read the labels on yogurt and other fermented products to see what strains that they are using.  Avoid products that do not properly list probiotics strains.

Probiotic strains that are histamine producers:

  • Lactobacillus bulgaricus
  • Lactobacillus casei
  • Lactobacillus reuteri
  • S. thermophilus*

These stains should be avoided.  Along with fermented products, be careful with probiotic supplements. Always read the label.  For instance, S.thermophilus is commonly used in broad-spectrum supplemental probiotics.

What Are the Best Probiotics for Histamine Intolerance?

Just like there are probiotic strains that promote histamine, there are strains that degrade histamine.  So along with DAO which blocks absorption, these strains degrade and breakdown histamine.  These are also commonly found in fermented foods and dietary supplements.

  • Bifidobacterium infantis
  • Bidobacterium longum
  • Lactobaccillus gasseri
  • Lactobacillus rhamnosus
  • Lactobacillus plantarum
  • Lactobacillus salivarius

Using probiotic supplementation is a great way to improve your gut microbiota and resolve histamine intolerance.  But don’t forget to add in the healthy foods that contain prebiotics to truly heal leaky gut and dysbiosis.

Some of the foods that high in healthy prebiotics like apples, onions, garlic, leeks, asparagus and even barley are all high in prebiotics.  Root vegetables like beets and sweet potatoes provide the gut bacteria with the food that the good bacteria need to flourish.  If you having problems digesting these foods, you might need a digestion tune-up.  Check out my FREE Health Assessment to get started.

 

Functional Nutrition Approach to Healing Histamine Intolerance

To end the madness of elimination dieting and to enjoy wine and cheese again, start with my FREE Health Assessment.  Followed up my complimentary 15-minute consult, begins the journey of getting to the root cause of your food intolerance.

Histamine intolerance, like most intolerances, did not occur overnight.  Nor, were you born with it.  Over the years, gut health, hormonal imbalances, medications, poor diet, and chronic stress can take its toll on our gut.

That is why functional nutrition using a comprehensive health history and profile.  From there it might be recommended to conduct integrative testing like a stool or organic acid testing.

Genomic testing is highly recommended as it involves not just variants that can impact enzyme production, but variants that have an impact on your gut health.

In addition, some of these variants can have an impact not just on food intolerances but autoimmune conditions like psoriasis.  For me, genomic testing was a game-changer as I finally got down to the root cause of my histamine intolerance and autoimmune skin conditions.

 

  1. Histamine and histamine intolerance, Laura Maintz and Natalija, American Journal Clinical Nutrition, 2007;85:1185-96
  2. Headaches, Hives and Heartburn Could Histamine be the Cause, Chris Kresser
  3. Degradation of Histamine by Lactobacillus Plantarum Isolated From Miso Products, Kung, et al, PMID: 28885051
  4. Probiotic Lactobacillus Rhamnosus Downregulates FCER1 and HRH4 Expression in Human Mast Cells, Oksaharju, et al, PMID: 21390145
How Well Will You Survive COVID-19?

How Well Will You Survive COVID-19?

How Well Will You Survive COVID-19?

Top experts are predicting that 40-60% of Americans will get the coronavirus.  Other experts are saying this number could be as high as 80% by the end of 2020.  So, the question really is not whether you are going to get the virus but how well you will survive and overcome this infection.    

We know that people who are over the age of 80 will be the hardest hit and will most likely require advanced medical treatment.  But why has the disease killed younger Americans, for instance – a 34-year-old California man who had asthma who recently died from this virus.  

Looking at what occurred in China and the United States the death rate from the coronavirus was the highest with those who had underlying conditions.  For China it was the death rate was highest with those with cardiovascular disease; for the US it was renal (kidney) disease.  

Following closely behind were people who had diabetes, chronic lung disease and immunocompromised were more likely to not survive this virus.

Interestingly enough obesity is highly linked to these chronic diseases.  This would make countries with high rates of diabetes and obesity like the US more risk for those contracting this virus to end up in ICU or death. 

Why are people with these conditions are more likely to suffer adverse outcome?

First of all, people who are overweight, diabetic and those that have cardiovascular disease have immune systems that are more challenged.  For instance, it is a known fact that those with diabetes have a harder time battling infections.  

In addition, those struggling with these chronic conditions are almost always struggling with oxidative stress and inflammation.  Oxidative stress is where the body does not have enough antioxidants on board to eliminate toxic substances known as reactive oxygen species.  With oxidative stress, our immune system is constantly being challenged creating an environment that makes us more vulnerable to infection.  

With an immune system that is constantly trying to reduce inflammation and fight infection, it is more likely to experience what is referred to as the “cytokine storm”.  This is where our bodies overproduce immune “messengers” in an attempt to fight off infection.  

How Does the Body Fight Viral Infections?

The first step in fighting virus infections is a direct action against the virus itself.  This can be done with a healthy diet rich in vegetables, fruits, herbs like parsley. In addition, herbs like elderberry and astragalus have antiviral properties and have been used for years to help fight viral infections like the common cold.

Once the virus enters our system, its first task at hand is to enter our cells and start replicating itself.  They actually hijack our cells and in the case of the coronavirus, its preferred cells are those that have cell receptors for the enzyme ACE2.  This is an enzyme that plays a major role in managing our blood pressure. ACE2 can also be found in high amounts in our lungs, kidney, liver and the gastrointestinal tract (GI).  

Immune support is also needed not to just boost the immune system to make sure it is in harmony or balance.  A “boosted” immune may lead to the cytokine storm or promote excessive inflammation. It is the balance of the immune system that is vital to surviving this infection.  Well, to be honest, all infections and for those struggling with autoimmune conditions.

Whole-body support brings the best weapon against the COVID-19 virus.  Even though these are stressful times as we spend our time in isolation, it is a time for reflection.  Without adequate sleep, stress reduction, physical exercise and a balanced diet, you will lose the battle right from the start.  

The 4 Key Components To Fighting Viruses

  • AntiViral – Zinc, Selenium, Iodine, Elderberry, Astragalus 
  • Anti Replication – Folate, Betaine, Polyphenols, Selenium, Zinc, NAC
  • Immune Nutrition – Low Carbohydrate Diet, Adequate Protein, Zinc, Vitamin D3, & Vitamin A
  • Whole Body Support – Adequate Sleep, Reduce Stress, Physical Exercise

 

 

What About Genomics and COVID-19

Research is coming out daily on just how does this virus works and what role does our genomics/genetics play in this battle.  This helps us to answer the question as why do some people get this virus and have few symptoms. While others end up in ICU.

It also helps to answer why people with underlying conditions like heart disease and lung conditions tend to end up in ICU.  And, why some will end up with permanent damage to their lungs.

What Genomic Variants Will Have An Impact?

There are now genomic variants or single nucleotide polymorphisms (SNPs) that have been linked to how well you will win this battle if you were to get COVID-19.  Some are extremely complicated while others relate highly to nutrition and lifestyle.

Most of these variances or SNP’s relate to how well our body is able to fight the virus from replicating.  They are also related to how well our bodies manage inflammation and can keep our immune system in harmony.

Relevant SNP’s to the COVID-19

 

ACE2

People who have variants in ACE2 tend to have higher blood pressure and sensitivity to salt.  With this variant, one would produce less of this enzyme and therefore reduced cell receptors.  This technically means that the virus would have less of a chance to “dock” and invade the cell.

But the jury is still out on this one.

Most of the underlying conditions like heart disease and diabetes usually come with high blood pressure.  So, to support this variant, it is recommended to stick with a lower salt diet and make sure you manage your blood pressure.

Bioactives Support COVID 19

Does Melatonin Help?

Melatonin, a neurotransmitter produced by the body, can address variants in NLRP3, a compound that promotes inflammation to help fight infection.  We produce melatonin mostly while we sleep.

As we age, however, we produce less and less melatonin, so it is crucial especially for people older than 60 to get adequate sleep.  Dietary supplementation is not a bad idea especially if you are older than 60 years old.

The production of melatonin is also impacted by our body’s ability to methylate which depends on folate, vitamins B12, B2, and betaine.  If you SNP’s in this pathway, this may impact your ability to produce melatonin.

Nitric Oxide & Vitamin C

The enzyme known as NOS helps to produce nitric oxide which is known to inhibit the replication of this virus.  It is also responsible for managing blood pressure.

In order to produce nitric oxide, vitamin C is needed as a co-factor.  What if you SNP’s in vitamin C and NOS most notably, NOS3 or eNOS? Your production of nitric oxide would be limited, reducing your ability to fight off COVID-19.

Fermented Foods Sour Cream Sauerkraut

Will Fermented Foods Help?

Fermented foods and foods high in probiotics are crucial to our immune system and the health of our GI system.  But for those with variants in FUT2, it is even more important that they maintain a diet high in complex carbohydrates and fermented foods.

What does FUT2 do?  It helps us to metabolize and absorb vitamin B12 crucial for the methylation pathway.  And, for those who have this variant along with MTHFR, it is even more important to maintain a diet rich in probiotics and prebiotics.

Not only do probiotics and prebiotics support FUT2 but they also support another variant known as NOD2.  NOD2 plays a crucial role in our immune system by recognizing bacteria and viruses, stimulating our immune system.  In addition to probiotics, organic bone broth will support this variant.

Powerful Antioxidants Our Body Produces

To fight off this virus and protect our DNA, we need powerful antioxidants like superoxide dismutase (SOD3).  This enzyme is highly dependent on zinc and copper and for those with a variant in SOD3, it is very important for them to consume foods high in zinc.  It is estimated that 30% of the world’s population is deficient in this nutrient especially for a society that consumes a vegetarian or vegan diet.

Foods high in zinc are oysters, red meat, eggs, yogurt, and cashews.  If you choose to supplement, do not go over 30-50 grams without sufficient copper.  I like to recommend that with supplementation, to increase foods high in copper like dark chocolate, sesame seeds, spirulina.

 

What is a COVID-19 Genomic Report

These are just a few of variants that are known to play a role in how well your body will fight COVID-19.  Our immune system is truly complex and the more we learn about how our genomics plays a role in our immune system, the more we can tailor a nutrition and lifestyle program.

Most of how the body fights infection involve a delicate balance between inflammation, fighting infection and the calming down of that infection as the body heals.  Whether you are talking about our innate or our adaptive immune system, it is all about balance. And, that depends on nutrients, bioactives and our lifestyles.

What if you could know how you target your “clinks in our genomic armor” and develop a true defense system?  That is why I am now offering two genomic packages at a great value.

**Disclaimer – This advice is not to take the place of your healthcare professional.  Please make sure that if you are having symptoms to contact your doctor immediately.  Be Safe, Be Healthy

 

Book Your 23andMe/Ancestry Package Today!

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